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Describe the pathophysiological basis for this type of hypersensitivity reaction.

Describe the pathophysiological basis for this type of hypersensitivity reaction..

A 19 month old infant presents with marked leg swelling, pain, and irritability to walk within 6 hours of receiving booster vaccinations.

Past medical history:
Primary immunizations received at 6, 10, and 14 weeks of age consisting of trivalent oral polio vaccine administered by mouth, hepatitis B virus vaccine, Haemophilus vaccine and diphtheria, pertussis and tetanus vaccine. No other childhood illnesses.

Allergies:
No prior adverse reactions noted

Physical Exam:
Vitals 38.5 degree Celsius
Respiratory rate, blood pressure and Heart Rate: normal for age
Musculoskeletal: marked swelling of the right thigh with tenderness; no discernable edema of the left thigh and no generalized edema
Skin: erythema of right thigh

Question answers should be based on evidence found in readings and from peer-reviewed literature. At least two sources must be used and cited in APA format for each question. Only one source can be a textbook. Resources should generally be within 5 years unless you are explaining the pathophysiology of a disease or providing pertinent background information

Discussion Questions:

  1. Review the types of hypersensitivity reactions, describe what type of hypersensitivity reaction is involved in this case, and support with evidence.
  2. According to national guidelines, what would you advise parents regarding further immunization practices?
  3. Describe the pathophysiological basis for this type of hypersensitivity reaction.

Describe the pathophysiological basis for this type of hypersensitivity reaction.

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